In this review, we aim to help clinicians better understand the pathology, diagnosis, and novel therapies in PGL and how these have evolved over the past 10 years. Other definition such as “double-protein” or “double expressor” refer to the coexpression of 2 oncogenes (MYC and Bcl-2) on a high percentage of tumor cells based on IHC staining.54,55 Double expressor and double-hit lymphomas have prognostic implications in DLBCL, but their use in primary gastric B-cell lymphomas remains unclear. This staging system is known as the Lugano Modification of the Ann Arbor staging system. Genentech does not recommend and does not endorse the content on any third-party websites. In H pylori-negative gastric MALT lymphomas, the theory that infection leads to lymphomagenesis and the presence of lymphoma loses validity. Many intricate differences exist among tumor types and across Simply select your manager software from the list below and click on download. proteins and their associated pathways.1,2 How cancer cells
Create a link to share a read only version of this article with your colleagues and friends. The EUS has been used to determine the eradication of H pylori and the outcome of MALT lymphoma treatment. For permissions, please e-mail: journals.permissions@oup.com, This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (.
This staging system was adopted by the eighth edition of the Cancer Staging Manual of the American Joint Committee on Cancer. The literature has reported that approximately 75% of H pylori-positive gastric MALT lymphomas obtain complete remission after the eradication of these bacteria with antibiotic therapy, supporting the association between H pylori infection and the presence of MALT.34,35 Lymphoid cells attract to gastric MALT tissue by a chronic H pylori infection. Literature reported that MALT lymphomas in the stomach with more than 1%58 or more than 5%60 of diffuse large blasts, but no overt DLBCL, showed a worse outcome after radiotherapy independently if the patient received chemotherapy and/or responded less often to H pylori eradication therapy. Wataru Munakata, Takashi Terauchi, Dai Maruyama, Hirokazu Nagai, Revised staging system for malignant lymphoma based on the Lugano classification, Japanese Journal of Clinical Oncology, Volume 49, Issue 10, October 2019, Pages 895–900, https://doi.org/10.1093/jjco/hyz111. The second one is related to an infectious cause different than H pylori, for example, infections associated with C jejuni.
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