ausgedehnt werden. Diffuse large B-cell lymphoma (DLBCL) is a cancer of B cells, a type of lymphocyte that is responsible for producing antibodies. Typischerweise führt das diffuse großzellige B-Zell-Lymphom durch eine rasche Vermehrung und Ansammlung von Tumorzellen in lymphatischen Organen zu einer Vergrößerung von Lymphknoten und Milz. [14], Diagnosis of DLBCL is made by removing a portion of the tumor through a biopsy, and then examining this tissue using a microscope. [8] An underlying immunodeficiency is a significant risk factor for development of the disease.
[12] Some cases of DLBCL, NOS, while not included in the 2016 World Health Organization's classification, are clearly associated with, and caused by, chronic infection by the bacterium, Helicobacter pylori. Flow Diagnosis: DLBCL … Patients afflicted with the latter syndrome have very short survival times. Zusätzliche Hinweise auf eine ungünstige Prognose geben die Mutation von zwei oder drei der Gene MYC, BCL-2 und BCL-6 (double- bzw.
Significant and potentially lethal therapeutic complications of this therapy included development of the cytokine release syndrome (21% of cases), neurotoxicity, i.e. Die Krankheit lässt sich meist gut mit einer Chemotherapie behandeln. ", "CAR T cell therapy for B-cell lymphomas", "How I manage patients with relapsed/refractory diffuse large B cell lymphoma", "Efficacy and safety of chimeric antigen receptor-T cells in the treatment of B cell lymphoma: a systematic review and meta-analysis", "CAR-T Cell Therapy in Diffuse Large B Cell Lymphoma: Hype and Hope", "The European Medicines Agency Review of Kymriah (Tisagenlecleucel) for the Treatment of Acute Lymphoblastic Leukemia and Diffuse Large B-Cell Lymphoma", "FDA Approval Summary: Axicabtagene Ciloleucel for Relapsed or Refractory Large B-cell Lymphoma", "Study to Evaluate the Efficacy and Safety of CUDC-907 in Patients With RR DLBCL, Including Patients With MYC Alterations", "Study to Assess the Safety, Tolerability and Pharmacokinetics of Fimepinostat (CUDC-907) in Patients With Lymphoma", "High-grade B-cell lymphoma: a term re-purposed in the revised WHO classification", "Testing a New Anti-cancer Drug Combination, Entinostat and GSK525762C, for Advanced and Refractory Solid Tumors and Lymphomas", "A Study to Evaluate Safety, Pharmacokinetics, and Clinical Activity of Combination of RO6870810 and Venetoclax, With or Without Rituximab, in Participants With Relapsed/Refractory DLBCL and/or High-Grade B-Cell Lymphoma and/or High Grade B-Cell Lymphoma With MYC and/or BCL2 and/or BCL6", "Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks", "Helicobacter pylori-related diffuse large B-cell lymphoma of the stomach: a distinct entity with lower aggressiveness and higher chemosensitivity", "Helicobacter pylori eradication in gastric diffuse large B cell lymphoma", "A multicenter prospective study of first-line antibiotic therapy for early-stage gastric mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma with histological evidence of mucosa-associated lymphoid tissue", "A review of EBV-positive mucocutaneous ulcers focusing on clinical and pathological aspects", "EBV-Positive Lymphoproliferations of B- T- and NK-Cell Derivation in Non-Immunocompromised Hosts", https://en.wikipedia.org/w/index.php?title=Diffuse_large_B-cell_lymphoma&oldid=978076536, Creative Commons Attribution-ShareAlike License, This page was last edited on 12 September 2020, at 19:18. Some cases of PEL also involve the gastrointestinal tract and lymph nodes. [24] Cases with a follicular pattern of tissue infiltrates often have indolent disease and an excellent prognosis following excision and may not need chemotherapy. Infektionsserologie v.a.
[22] Neoplastic cell expression of CD30, found in 10-15% of DLBCL, NOS cases is a favorable prognostic indicator. Monate, danach auf sechs Monate bis zur Vollendung des fünften Jahres nach Therapieende [12] The poor prognosis of this disease has been significantly improved by rituximab or similar immunochemotherapy drugs but significant proportions of these responding cases relapse, often with central nervous system involvement. [41] GSK525762, an inhibitor of the BET family of proteins, suppresses expression of the MYC gene and is undergoing a phase I clinical trial[42] for the treatment of high-grade B-cell lymphoma with MYC, BL2, and/or BL6 rearrangements (i.e. In the remaining ~30% of other cases, the disease begins as an extranodal lymphoma, most commonly in the stomach,[12] or, less commonly, in other sites such as the testicles, breasts, uterus, ovaries, kidneys, adrenal glands, thyroid gland, or bone. Diffuse large B-cell lymphoma (DLBCL) is a cancer of B cells, a type of lymphocyte that is responsible for producing antibodies.It is the most common form of non-Hodgkin lymphoma among adults, with an annual incidence of 7–8 cases per 100,000 people per year in the US and UK. Bei jungen Hochrisikopatienten werden in der Regel acht Zyklen mit R-CHOEP-14,
[5] The first sign of this illness is typically the observation of a rapidly growing mass or tissue infiltration that is sometimes associated with systemic B symptoms, e.g.
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