[1], There are several synonymous and obsolete terms for FL such as CB/CC lymphoma (centroblastic and centrocytic lymphoma), nodular lymphoma,[2] Brill-Symmers Disease, and the subtype designation, follicular large-cell lymphoma. The use of PET/CT imaging is strongly recommended to insure that the FL is localized. It originates from the follicular center B cells. Currently used indicators for this include the disease's: 1) histology; 2) subtype; 3) predicted indolence and potential for transformation; and 4) extent of disease as measured by clinical examinations, bone marrow biopsy to determine bone marrow involvement, and PET/CT imaging of the chest, abdomen, pelvis, and any areas outside of these regions if physical examination suggests involvement. Surgery followed by less strenuous or even no chemotherapy may prove to be the optimal treatment for this disease. A watch-and-wait strategy has been a generally recommended method for the initial treatment of the disease.
[13] These enlargements may have been present for months to years and during this time waxed and waned in size.
[42], The lesions in PTFL consists of infiltrates containing rapidly proliferating centrocytes and centroblasts that lack the t(14:18)(q32:q21.3) translocation but nonetheless often overexpress the BCL2 gene. These studies also found no overall survival time benefit between the RB and R-CHOP regimens. [4] However, most cases of FL have a less favorable prognosis at some stage of their disease and will therefore require intervention. Bcl2 functions to inhibit programmed cell death thereby prolonging cell survival. None of these protein markers or genomic abnormalities are diagnostic for FL, e.g.
[7], Pediatric-type follicular lymphoma (PTFL) was initially reported to occur in children ages 1–17 years old (median age ~13-14) but more recently has been reported to occur in adults. build-up of fluid in the abdominal or pleural cavities); poor performance status due to the disease; elevated levels of serum lactose dehydrogenase or beta-2 microglobulin;[4] presence of localized bone lesions; kidney involvement; reduced levels of circulating blood platelets or any of the various types of white blood cells; onset of significant pruritus (i.e. The disease may present with signs and symptoms typical of the common type of follicular lymphoma. [13], Patients with asymptomatic but not localized low grade FL,[8][53][54] gastrointestinal tract FL,[34] and pediatric-type follicular lymphoma[42] have been served by careful follow-up without therapeutic intervention. 1 in 100,000) of circulating nucleated blood cells bearing this t(14:18)q32:q21) translocation are found in 50-67% of otherwise healthy individuals. a follicular lymphoma in which GI tract lesions were prominent parts of the disease. These patients generally present with advanced, bulky disease that may be accompanied by extra-nodal lesions and B-symptoms. a translocation between position 32 on the long (i.e. Follicular lymphoma is the most common type of of low-grade non-Hodgkin lymphoma (NHL). Bcl2). Stay informed withnews, alerts andother resources. The aim of treatment is to get you into remission (where the amount of lymphoma is significantly reduced). Follicular Lymphoma: Long-term Survivorship Since FL is generally characterized by multiple disease relapses after responses to a variety of treatments, patients in remission should have regular visits with a physician who is familiar with their medical history and the treatments they have received. follicular lymphoma oder follicle centre lymphoma) ist ein malignes Lymphom und zählt zu den B-Zell-Non-Hodgkin-Lymphomen (B-NHL). 100% completed remissions with no recurrence of disease in 15 child and adolescent patients observed for 4–96 months.
To learn more about a specific type of lymphoma, select from the following menu: The Lymphoma Research Foundation’s mission is to eradicate lymphoma and serve those impacted by this blood cancer. We don’t know exactly what causes follicular lymphoma. stem cells taken from patient) or allogeneic (i.e.
There is little consensus regarding the guidelines to be used to define the prognosis and treatment for FL at its presentation or during its course.. [37] These signs and symptoms may include abdominal pain, bowel obstruction,[11] persistent nausea and vomiting, hematochezia (i.e.
[6], FL is a broad and extremely complex clinical entity with a wide range of manifestations[7] which have not yet been fully systematized.
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