2019 Nov;24(11):e1236-e1250. info@ehaweb.org. CC-122, a novel cereblon-modulating agent, in combination with obinutuzumab (GA101) in patients with relapsed and refractory (R/R) B-cell non-Hodgkin lymphoma (NHL). Zinzani P, Wagner-Johnston N, Miller C, et al. The uncertainty of the long-term benefit of rituximab maintenance following rituximab-containing induction therapy was also discussed in a recent meta-analysis.29, For relapsed patients, the role and timing of auto- or allogeneic transplantation remains controversial.
31. 49. 2020 Sep 22;4(18):4451-4462. doi: 10.1182/bloodadvances.2020002546. The compound was well tolerated. 53. Register with us for free
your express consent. 4. Kahl BS, Yang DT. 5. 10. An email with instructions to reset your password will be sent to that address.
Radioimmunotherapy (90yttrium-ibritumomab-tiuxetan) may also represent an effective therapeutic approach in elderly patients with comorbidities not appropriate for transplantation.37. In the randomized GADOLIN trial, obinutuzumab plus bendamustine was compared with bendamustine alone in relapsed patients who were refractory to rituximab.44 The use of obinutuzumab and bendamustine significantly improved PFS and also OS and clearly demonstrate that obinutuzumab is also active in rituximab-refractory patients. 28. A phase I trial combining idelalisib, lenalidomide, and rituximab stopped early.65 Similarly, the combination of ibrutinib, lenalidomide, and rituximab also generated unexpected side effects.66. 27. Phase 2 trial of entospletinib (GS-9973), a selective Syk inhibitor, in indoelent non-Hodgkin's lymphoma (NHL). Gopal AK, Schuster SJ, Fowler NH, et al. Huet S, Tesson B, Jais JP, et al. In the DYNAMO-trial, 83 patients with FL refractory to chemotherapy and rituximab achieved an ORR of 41%.49 The median PFS was 8,3 months and the median OS was 11,1 months. Rituximab maintenance improves overall survival of patients with follicular lymphoma-Individual patient data meta-analysis. Morschhauser F, Tilly H, Chaidos A, et al. Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Bendamustin plus rituximab (B-R) versus CHOP plus rituximab (CHOP-R) as first-line treatment in patients with indolent lymphomas: nine-year updated results from the StiL NHL 1 study. Rummel MJ, Maschmeyer G, Ganser A, et al. Conclusions: Andorsky DJ, Yacoub A, Melear JM, et al. 46. 44.
Although this trial failed the primary endpoints, the study is of interest since it suggests equivalence between immunochemotherapy and a nonchemotherapy approach. The overall prognosis of patients with follicular lymphoma (FL) has substantially improved over the last decades. Beside rituximab the only antibody which has already been approved in the US and Europe for use in FL is obinutuzumab.
In first line therapy, early identification of patients with a potentially aggressive course is required.
Improvements in observed and relative survival in follicular grade 1-2 lymphoma during 4 decades: the Stanford University experience. With the introduction of the aggressive chemotherapies or purine analogs at the end of the seventies the median overall survival (OS) for all patients with low-grade FL (grade I/II) reached 18.5 years, and there was further improvement after the introduction of rituximab.1 Using immunochemotherapy for advanced stage symptomatic patients FL is now a relapsing and remitting disease with a 5-year OS of more than 90% for the majority of patients.2 However, certain subgroups of patients still have worse outcome and patients diagnosed in their forties and fifties will still have their life expectancy shortened by this disease. In general, cytopenias can occur but constitutional symptoms of fever, nightsweats, and weight loss are uncommon. Results from a phase 1/2 study of INCB050465, a highly selective and highly potent PI3Kdelta inhibitor, in patients with relapsed or refractory B-cell malignancies (CITADEL-101). Currently, there is a major interest in the role of immune checkpoint inhibitors, so called blocker of the programmed cell death protein 1 (PD-1).
HemaSphere, 2018;00:00. http://dx.doi.org/10.1097/HS9.0000000000000156. 41. 2011 Jul;17(7):1051-7. doi: 10.1016/j.bbmt.2010.11.004. 18. 35. Morschhauser F, Fowler NH, Feugier P, et al. Tomblyn MR, Ewell M, Bredeson C, Kahl BS, Goodman SA, Horowitz MM, Vose JM, Negrin RS, Laport GG. may email you for journal alerts and information, but is committed
The combination was well tolerated.
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