Hematoxylin and eosin (H&E) and immunohistochemical staining of ALCL. Patients with ALK‐1–negative ALCL had higher OS rates than patients with other T‐cell lymphomas (3‐year OS rates of 68% compared with 40%, respectively). Autologous hematopoietic stem cell transplantation in peripheral T-cell lymphoma using a uniform high-dose regimen. Das PET/CT besitzt bei extranodalen nicht-kutanen Manifestationen, insbesondere im GI-Trakt, eine der CT überlegene Sensitivität. Die Inzidenz der extranodalen NK/T-Zell Lymphome vom nasalen Typ ist im asiatischen Raum am höchsten [1].
Unique gene expression program of human germinal center T helper cells. Shortened first-line high-dose chemotherapy for patients with poor-prognosis aggressive lymphoma. Blood 2015; 126 (1): 17–25. Of 27 enrolled patients (14 acute, 6 lymphomatous, 7 chronic ATL), the ORR was 54% with 7 CR. ASCO Career Center Conversely, ALK+ ALCL patients with a high IPI score have poor outcomes, and alternate strategies should be considered for this group.
Für eine Risikostratifizierung und Abschätzung der Prognose sind gegenwärtig mehrere Risiko-Scores in Verwendung.
Vorinostat and romidepsin have shown single-agent activity in CTCL,92,93 and vorinostat was approved by the Food and Drug Administration (FDA) in 2006 for the treatment of advanced and refractory CTCL. Long-term outcome of adults with systemic anaplastic large-cell lymphoma treated within the Groupe d'Etude des Lymphomes de l'Adulte trials.
J Clin Oncol 31:240-246, 2013. ATL is characterized by a clonal expansion of CD4+ T lymphocytes frequently associated with skin rash, lymph node and visceral involvement, and hypercalcemia.
The presence of a DUSP22 rearrangement was associated with reduced protein expression.38,39 An analysis of 73 patients with ALK− ALCL identified DUSP22 and P63 rearrangements in 30% and 8% of ALK− ALCL patients, respectively, but they were absent in ALK+ ALCL.40 These rearrangements were mutually exclusive and appear to have important prognostic relevance (see “Prognostic factors in ALCL”). Comparison of gemcitabin, cisplatin, and dexamethasone (GDP), CHOP, and CHOPE in the first-line treatment of peripheral T-cell lymphomas. Nine patients were treated with unconventional modalities such as surgery, radiotherapy, photopheresis, retinoic acid, and interferon alone or in combination with other agents. Management of T-Cell Lymphomas: Overcoming Challenges and Choosing the Best Treatment. A large single-center experience with allogeneic stem-cell transplantation for peripheral T-cell non-Hodgkin lymphoma and advanced mycosis fungoides/Sezary syndrome. Liu contributed equally to the current study. The increased incidence of T-NK-cell lymphomas in East Asia related to the frequency of endemic HTLV-1 and EBV infections. Peripheral T-cell lymphoma complicated by immunoglobulin A pemphigus: A case report and literature review.
Challenges and future directions in peripheral T‐cell lymphoma. Onkopedia, Hämophagozytische Lymphohistiozytose (HLH).
The impact was most evident in ALK+ ALCL (3-year EFS, 91% vs 57%), and a similar trend was observed for other nodal PTCLs, which included ALK− ALCL (60.7% vs 48.3%; P = .057).42 However, for all comparisons, the OS was not statistically different, and the analyses were not adjusted for the IPI.
Treatment outcomes of dose-attenuated CHOP chemotherapy in elderly patients with peripheral T cell lymphoma.
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