Because isoniazid has some monoamine oxidase inhibiting activity, an interaction with tyramine-containing foods (cheese, red wine) may occur. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Streptomycin should not be used because it has been shown to have harmful effects on the fetus. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Carbamazepine levels should be determined prior to concurrent administration with isoniazid, signs and symptoms of carbamazepine toxicity should be monitored closely and appropriate dosage adjustment of the anticonvulsant should be made3. The options listed above must be adjusted for the pregnant patient. Ciba Pharmaceuticals, Summit, NJ. The agar proportion method (CLSI, M24-A2) utilizes middlebrook 7H10 or 7H11 medium impregnated with isoniazid at two final concentrations, 0.2 mcg/mL and 1.0 mcg/mL and tubercle bacilli at a 10-2 to 10-4 dilution of 0.5 to 1.0 McFarland turbidity standard.10 MIC99 values are calculated by comparing the quantity of organisms growing in the medium containing drug to the control cultures. Diamine oxidase may also be inhibited, causing exaggerated response (e.g., headache, sweating, palpitations, flushing, hypotension) to foods containing histamine (e.g., skipjack, tuna, other tropical fish). Susceptibility test results obtained by the two different methods discussed above cannot be compared unless equivalent drug concentrations are evaluated. Approximately 50 percent of Blacks and Caucasians are "slow inactivators" and the rest are "rapid inactivators"; the majority of Eskimos and Orientals are "rapid inactivators.". 6- or 9-month daily regimen of INH (6H or 9H) , with pyridoxine (vitamin B6) supplementation.
The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. The incidence is higher in "slow inactivators". Isoniazid has been shown to have an embryocidal effect in rats and rabbits when given orally during pregnancy. Other factors associated with an increased risk of hepatitis include daily use of alcohol, chronic liver disease and injection drug use. Patients with this degree of INH intoxication are likely to have hypoventilation. Isoniazid should not be administered with food. All rights reserved. The initial treatment regimen should consist of isoniazid and rifampin. Pharmacology, adverse reactions, warnings and side effects. Susceptibility Testing of Mycobacteria, Nocardiae, and Other Aerobic Actinomycetes; Approved Standard-Second Edition. Rheumatic syndrome and systemic lupus erythematosus-like syndrome. Isoniazid should be used as a treatment for active tuberculosis during pregnancy because the benefit justifies the potential risk to the fetus. It is freely soluble in water, sparingly soluble in alcohol and slightly soluble in chloroform and in ether. If the quantity of isoniazid ingestion is unknown, then consider an initial intravenous bolus of pyridoxine of 5 grams in the adult or 80 mg/kg in the child. The preferred initial treatment regimen is INH, rifampin (RIF), and ethambutol (EMB) daily for 2 months, followed by INH and RIF daily, or twice weekly for 7 months (for a total of 9 months of treatment). Opportunistic Infections and Coinfections.
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Concomitant administration of pyridoxine (B6) is recommended in the malnourished and in those predisposed to neuropathy (e.g., alcoholics and diabetics).
All rights reserved. The drug should be restarted in very small and gradually increasing doses and should be withdrawn immediately if there is any indication of recurrent liver involvement. Severe metabolic acidosis, acetonuria and hyperglycemia are typical laboratory findings. O 0. DOT can be achieved with daily, twice weekly or thrice weekly regimens and is recommended for all patients.
Conditions: caloric undernutrition. Isoniazid has not been shown to be carcinogenic in humans. Routine use of pyrazinamide is also not recommended in pregnancy because of inadequate teratogenicity data. Find out what health conditions may be a health risk when taken with Rifapentine Oral Isoniazid is slowly affected by exposure to air and light. Multiple-drug resistant tuberculosis (i.e., resistance to at least isoniazid and rifampin) presents difficult treatment problems. The benefit of preventive therapy also should be weighed against a possible risk to the fetus. Isoniazid tablets, USP are recommended for all forms of tuberculosis in which organisms are susceptible. Inclusion or absence of a drug label on the ClinicalInfo site does not imply endorsement or lack thereof by ClinicalInfo. In most instances, enzyme levels return to normal and generally, there is no necessity to discontinue medication during the period of mild serum transaminase elevation.
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