NLM Disease characteristics, patterns of care, and survival in very elderly patients with diffuse large B-cell lymphoma. Oncol. XY collected and analyzed the data and wrote the paper. Patients with non-Hodgkin lymphoma are at significantly increased risk of second primary malignancies (SPM). Trends in extranodal diffuse large B-cell lymphoma incidence rates (1973–2015): the SEER-9 registry database. Front. | Graph shows increasing survival from the 1970s to 2000s. The standardized incidence ratio (SIR), absolute excess risk (AER), and 95% confidence intervals (CIs) were calculated. The stage was divided into early (Ann Arbor Stage I/II) or advanced (III/IV) stage. Search for other works by this author on: © 2014 by The American Society of Hematology, Copyright ©2020 by American Society of Hematology, 902. Major A, Smith DE, Ghosh D, Rabinovitch R, Kamdar M. Cancer. Copyright © 2017 Elsevier Inc. All rights reserved. Severe immune dysregulation such as seen in autoimmune (AI) disease is known to act as a significant risk factor for diffuse large B-cell lymphoma (DLBCL). Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60). We examined the baseline clinical characteristics for patients with B-cell-mediated AI disease, plotted the overall survival and lymphoma-related survival (LRS) for these groups, and compared the median survival times. Most of the deaths occurred in man (4,745 [54.068]), early stage (5,377 [61.269]), the elderly (6,795 [77.427]), and white group (7,437 [84.742]). doi: 10.1182/blood-2010-05-283358, 28. HomeSurveillance, Epidemiology, and End Results Program Surveillance, Epidemiology, and End Results Program SEER is an authoritative source for cancer statistics in the United States. There was significantly higher risk of tumors of anus & colorectal, liver, kidney, thyroid, Kaposi sarcoma and hematologic malignancies within 5 years of latency. Blood Adv. had demonstrated that some specific extranodal sites have a better predictive value than the number of extranodal sites involved (7). In non-Hodgkin lymphoma (NHL), particularly diffuse large B-cell (DLBCL) and follicular (FL) lymphomas, the prevalence, burden of disease, including that of relapse/recurrence, and quality of life (QoL) play a role in how novel treatment strategies are evaluated. For advanced stage patients, the incidence and incidence-based mortality rates started from a rapid increase, with a change occurring 2007 and 1990, respectively, that the incidence rate turned to decrease and mortality rates leveled off. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The present study aimed to explore the incidence and mortality trends of extranodal DLBCL by primary site involved and patient demographic characteristics from the Surveillance, Epidemiology, and End Results (SEER) cancer registry during 1973–2015. Therefore, the incidence-based mortality rate declined 3 years earlier than the incidence rate.
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